PhD student position
We offer an interesting and challenging job in an international environment focusing on education, research, public-sector consultancy and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. Applications are invited from suitably qualified candidates for a position funded by the Marie Skłodowska-Curie project “ASCTN-Training” within the Horizon 2020 programme of the European Union, starting October 1, 2019. The appointment will be on a temporary basis for a maximum period of 3 years (PhD student) and will be placed at the “Stem Cells” Laboratory, Division of Neuroscience, San Raffaele Scientific Institute, Milan ASCTN-Training is a four-year project, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813851. ASCTN-Training is addressing existing gaps within Human Stem Cell-based Neuronal disorders (NDs) Modelling (NDM) for research to develop new medicines for the treatment of neurological disorders (e.g. Parkinson´s (PD), Huntington´s (HD) and Demyelination’s (DM) diseases), which occur as a result of acute or progressive loss of cells, glial or neuronal, and structures and function in the brain. ASCTN-Training sets out with the ambition to educate and train students within and across different scientific disciplines: biotechnology (Human Pluripotent Stem Cells (hPSCs) neuronal and glial differentiation using brain-on-chip technology and microfluidics, 3D tissue engineering/cerebral organoids and nanoengineering of culture conditions), molecular biology (Ex vivo gene expression, Direct cellular reprograming, mouse genetic modification, single cell analysis), In vivo mouse manipulations (Animal models of NDs, stem cell transplants into the brain, scaffold implantation, direct tissue engineering).
The intended PhD student will be a member of a multi-disciplinary team and will be responsible for the generation of robust, new HD in vitro models by:
1. To develop the tools to directly reprogram human adult cells into DA neurons.
2. To perform genomic and epigenomic comparison of different reprogrammed DA neuronal cell types.
3. To establish new culture systems for patterned growth of human DA neurons.
4. To employ human reprogrammed DA neurons for deciphering pathophysiological mechanisms of Parkinson’s disease.
The candidate will have to accomplish the following tasks:
• Spend external stays at the Universidad Autónoma de Madrid and University of Dresden (subject to changes depending on project results).
• Participate in training events for researchers and Principal Investigators involved in the program.
• Report to the Project Manager which includes contributing to periodic scientific reports.
• Contributing to the reporting of project milestones and deliverables in accordance with EU deadlines.
• Promote and disseminate results involved in the program, which includes contributing to newsletters and participating in outreach events.
Applicants should submit a full CV with detailed description of her/his background and expertise together with contacts for recommendations to Vania Broccoli – email@example.com - firstname.lastname@example.org
Epigenetic mechanisms of brain development
and neuroinfantile disorders
iPS cell technology for
in vitro disease modeling
Developing gene therapy approaches
for neurological disorders
Pathological mechanisms of neuronal cell
loss in Parkinson’s disease
Genetic strategies of
neuronal cell reprogramming
Novel therapies based on
gene editing technologies
Novel translational research
programs for Dravet syndrome
New therapies for