Stem Cells and Neurogenesis Unit
Division of Neuroscience
San Raffaele Scientific Institute
Via Olgettina 58
TEL. Lab +39 02 26434612
TEL. Office +39 02 26434616
FAX +39 02 26436164
Broccoli Vania is leading the Unit of “Stem Cell and Neurogenesis” at the San
Raffaele Scientific Institute in Milan (Italy). He is a neurobiologist interested to unravel the molecular mechanisms that control key processes of brain development such as neural stem cell identity maintenance, neural commitment and migration, neural network establishment and function. Lately, his group has applied new technologies of direct cell reprogramming to convert mouse and human skin fibroblasts into functional dopaminergic neurons. Now, he aims to further strengthen these approaches to establish safe and efficient systems for producing functional human neurons suitable for cell replacement therapies in infantile neurological and neurodegenerative disorders. V. Broccoli has published 64 papers in international scientific journals with a Total Impact Factor (IF) = 492.2, with average IF=7.8/Journal, was cited 2732 in total, with an average citation per item of 42.6, H-index is 27 based on the ISI web of science. He contributed 5 chapters to scientific books and edited one special issue of the “Scientific American” Italian Edition.
Vania Broccoli established his laboratory in 2003 at the San Raffaele Scientific Institute and focused on revealing the molecular mechanisms controlling neuronal differentiation and cerebral cortex development. From 2000 to 2001, he worked at the Telethon Institute of Molecular Medicine (TIGEM) as associate scientist. As post-doctoral fellow, from 1996 to 1999, he worked in Prof. W.Wurst’s laboratory in Munich, unraveling the role played by the transcription factor Otx2 in shaping midbrain-hindbrain junction and controlling dopaminergic neuronal ontogenesis. From 1993-1996, as PhD student in Prof. E. Boncinelli’s laboratory, he studied the mechanisms of brain regionalization and differentiation, in particular, focusing on the Emx and Otx transcription factors during cerebral cortex development. He is contract Professor at the Medical School of the Vita-Salute San Raffaele University.
Major Funding of the PI
The Michael J. Fox Foundation ”Assessing the therapeutic potential of iDA neuronal cells in an autologous transplantation strategy. 2012.
Telethon (GGP11110) " Molecular bases and in vitro modeling of Cdkl5 dependent infantile neurological disorders". 2011-2014.
Telethon (GGP09117) "Congenital Rett syndrome: cellular and mouse models for the study of FOXG1 impact on forebrain neurogenesis". 2010-2013.
ERANET-Neuron (EU) "Modeling Parkinson’s disease by iPStechnology: generation of human affected dopaminergic neurons and gene disease correction by site-specific integration" 2009-2012.
Italian Ministry of Health - Young Researcher Award (RF12) “Derivation, characterization and preclinical applications of fibroblasts-derived iPS cells from patients affected by Parkinson’s disease” 2008-2011.
Telethon (GGP07181) “Identification of the Arx molecular mechanisms in controlling telencephalon development and GABAergic neuronal migration: implications for Arx dependent neurological diseases” 2007-2010.
ERANET-Rare Diseases (EU) “EURORETT: European Network onRett Syndrome” 2007-2010.
RSRF Rett Syndrome Research Foundation (USA) "Production and first analysis of an animal model for the “early seizure” Rettsyndrome variant: conditional inactivation of the murine Cdkl5 gene" 2007-2008.
Italian Ministry of Health “Trinucleotide (GCG) repeat expansion of the ARX gene and progressive dystonia in infancy” 2006-2007.
Telethon (GGP04141) "Unravelling the pathogenetic mechanisms of Arx mutations leading to several forms of mental retardation, epilepsy and XLAG" 2004-2006.
Italian National Program for Stem Cell Research (CS71) "Derivation and neural differentiation of mouse and bovine embryonic stem cells: an in vitro and in vivo comparative assessment with neural stem cells." 2004-2005. €120,000
EU, 5th framework program (FP5) "Neural degeneration and control of cell polarity" QLG3-CT-2002-01266. 2000-2002.