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Publications of the last 5 years


Dell'Anno MT, Caiazzo M, Leo D, Dvoretskova E, Medrihan L, Colasante G, Giannelli S, Theka I, Russo G, Mus L, Pezzoli G, Gainetdinov RR, Benfenati F, Taverna S, Dityatev A, Broccoli V. (2014)

Remote control of induced dopaminergic neurons in parkinsonian rats.

Journal of clinical Investigation 2014 Jun 17. Ahead of print.


Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah SA, Graf T, Broccoli V, Di Croce L. (2014)

Zrf1 is required to establish and maintain neural progenitor identity.

Genes and Development 28(2):182-197.


Colasante G, Simonet JC, Calogero R, Crispi S, Sessa A, Cho G, Golden JA, Broccoli V. (2013)

ARX Regulates Cortical Intermediate Progenitor Cell Expansion and Upper Layer Neuron Formation Through Repression of Cdkn1c.

Cereb Cortex. 2013 Aug 22. Ahead of print.


Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, Garavaglia B, Benz R, Altamura S, Goede JS, Muckenthaler MU, Levi S. (2013)

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

J Exp Med. 210(9):1779-1791.


Theka I, Caiazzo M, Dvoretskova E, Leo D, Ungaro F, Curreli S, Managň F, Dell'Anno MT, Pezzoli G, Gainetdinov RR, Dityatev A, Broccoli V. (2013)

Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors.

Stem Cells Transl Med. 2(6):473-479.


Broccoli V, Caiazzo M. (2013)

Nuclear receptors: Oxysterols detour to neurodevelopment.

Nat Chem Biol. 9(2):70-71.


Ricciardi S, Ungaro F, Hambrock M, Rademacher N, Stefanelli G, Brambilla D, Sessa A, Magagnotti C, Bachi A, Giarda E, Verpelli C, Kilstrup-Nielsen C, Sala C, Kalscheuer VM, Broccoli V. (2012)

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

Nat Cell Biol. 14(9):911-23. d


Tedesco FS, Gerli MF, Perani L, Benedetti S, Ungaro F, Cassano M, Antonini S, Tagliafico E, Artusi V, Longa E, Tonlorenzi R, Ragazzi M, Calderazzi G, Hoshiya H, Cappellari O, Mora M, Schoser B, Schneiderat P, Oshimura M, Bottinelli R, Sampaolesi M, Torrente Y, Broccoli V, Cossu G. (2012)

Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy.

Sci Transl Med. 4(140):140ra89.


Marinaro C, Pannese M, Weinandy F, Sessa A, Bergamaschi A, Taketo MM, Broccoli V, Comi G, Götz M, Martino G, Muzio L. (2012)

Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1.

Cereb Cortex. 22(10):2415-27


Broccoli V, Caiazzo M, Dell'Anno MT (2011)

Setting a highway for converting skin into neurons.

J Mol Cell Biol 3(6):322-3.


Di Stefano B, Maffioletti SM, Gentner B, Ungaro F, Schira G, Naldini L, Broccoli V (2011).

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Stem Cells 29(11):1684-1695.


Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, Sotnikova TD, Menegon A, Roncaglia P, Colciago G, Carninci P, Pezzoli G, Gainetdinov RR, Gustincich S, Dityatev A, Broccoli V (2011)

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts.

Nature 476(7359):224-227.


Lombardo A, Cesana D, Genovese P, Di Stefano B, Provasi E, Colombo DF, Neri M, Magnani Z, Cantore A, Lo Riso P, Damo M, Pello OM, Holmes MC, Gregory PD, Gritti A, Broccoli V, Bonini C, Naldini L (2011)

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Nature Methods 8(10):861-9.


Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, Böckers TM, Dityatev A, Sala C (2011)

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

J Biol Chem 286(40):34839-50.


Ricciardi S, Boggio EM, Grosso S, Lonetti G, Forlani G, Stefanelli G, Calcagno E, Morello N, Landsberger N, Biffo S, Pizzorusso T, Giustetto M, Broccoli V (2011)

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

Hum Mol Genet 20(6):1182-96.


Alvarez Dolado M, Broccoli V (2011)

GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity.

Neural Plast 2011:384216.


Giannelli SG, Demontis GC, Pertile G, Rama P, Broccoli V (2011)

Adult Human Muller Glia Cells are a Highly Efficient Source of Rod Photoreceptors.

Stem Cells 29(2):344-56.


Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V (2010)

An ES-like pluripotent state in FGF-dependent murine iPS cells.

PLoS One 5(12):e16092.


Sessa A, Mao CA, Colasante G, Nini A, Klein WH, Broccoli V (2010)

Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons.

Genes Dev 24(16):1816-26.


Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V*, Walsh CA* (2010) *co-corresponding authors

The apical complex couples cell fate and cell survival to cerebral cortical development.

Neuron 66(1):69-84.


Colleoni S, Galli C, Giannelli SG, Armentero MT, Blandini F, Broccoli V*, Lazzari G* (2010) *co-corresponding authors

Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors.

Exp Cell Res 316(7):1148-58.


D'Autilia S, Broccoli V, Barsacchi G, Andreazzoli M (2010)

Xenopus Bsx links daily cell cycle rhythms and pineal photoreceptor fate.

Proc Natl Acad Sci U S A 107(14):6352-7.


Ricciardi S, Kilstrup-Nielsen C, Bienvenu T, Jacquette A, Landsberger N, Broccoli V (2009)

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.

Hum Mol Genet 18(23):4590-602.


Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, Broccoli V (2009)

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity.

Dev Biol 334(1):59-71.


Di Stefano B, Prigione A, Broccoli V (2009)

Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.

Stem Cells Dev 18(5):707-16.


Publications (continue)



Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R (2008)

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Proc Natl Acad Sci U S A 105(15):5856-61.


Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V (2008)

Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.

Neuron 60(1):56-69.


Colasante G, Collombat P, Raimondi V, Bonanomi D, Ferrai C, Maira M, Yoshikawa K, Mansouri A, Valtorta F, Rubenstein JL, Broccoli V (2008)

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.

J Neuroscience 28(42):10674-86.


Ariani F, Hayek G, Rondinella D, Artuso R, Mencarelli MA, Rosseto A, Pollazzon M, Buoni S, Spiga O, Ricciardi S, Meloni I, Longo I, Mari F, Broccoli V, Zappella M, Renieri (2008)

FOXG1 is mutated in variant Rett syndrome.

Am J Hum Genet 83(1):89-93.


Rusconi L, Salvatoni L, Giudici L, Bertani I, Kilstrup-Nielsen C, Broccoli V, Landsberger N (2008)

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

J Biol Chem 283(44):30101-11.


Biressi S, Messina G, Collombat P, Tagliafico E, Monteverde S, Benedetti L, Cusella De Angelis MG, Mansouri A, Ferrari S, Tajbakhsh S, Broccoli V, Cossu G (2008) The homeobox gene Arx is a novel positive regulator of embryonic myogenesis

Cell Death Differ 15(1):94-104.


Cassano M, Biressi S, Finan A, Benedetti L, Omes C, Boratto R, Martin F, Allegretti M, Broccoli V, Cusella De Angelis G, Comoglio PM, Basilico C, Torrente Y, Michieli P, Cossu G, Sampaolesi M (2008)

Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis.

PLoS One 3(9):e3223.


Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V (2007)

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.

J Neuroscience 27(17):4786-98.


Gosens I, Sessa A, den Hollander AI, Letteboer SJ, Belloni V, Arends ML, Le Bivic A, Cremers FP, Broccoli V, Roepman R (2007)

FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.

Exp Cell Res 313(19):3959-70.


Deponti D, François S, Baesso S, Sciorati C, Innocenzi A, Broccoli V, Muscatelli F, Meneveri R, Clementi E, Cossu G, Brunelli S (2007)

Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.

J Cell Biol 179(2):305-19.


McKenzie O, Ponte I, Mangelsdorf M, Finnis M, Colasante G, Shoubridge C, Stifani S, Gécz J, Broccoli V (2007)

Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin-like enhancer of split dependent transcriptional repressor.

Neuroscience 146(1):236-47.


Colombo E, Giannelli SG, Galli R, Tagliafico E, Foroni C, Tenedini E, Ferrari S, Ferrari S, Corte G, Vescovi A, Cossu G, Broccoli V (2006)

Embryonic stem-derived versus somatic neural stem cells: a comparative analysis of their developmental potential and molecular phenotype.

Stem Cells 24(4):825-34.


Lazzari G, Colleoni S, Giannelli SG, Brunetti D, Colombo E, Lagutina I, Galli C, Broccoli V (2006)

Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro.

Stem Cells 24(11):2514-21.


Ferrer I, Kapfhammer JP, Hindelang C, Kemp S, Troffer-Charlier N, Broccoli V, Callyzot N, Mooyer P, Selhorst J, Vreken P, Wanders RJ, Mandel JL, Pujol A (2005)

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.

Hum Mol Genet 14(23):3565-77.


Collombat P, Hecksher-Sřrensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A (2005)

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

Development 132(13):2969-80.


Mari F, Azimonti S, Bertani I, Bolognese F, Colombo E, Caselli R, Scala E, Longo I, Grosso S, Pescucci C, Ariani F, Hayek G, Balestri P, Bergo A, Badaracco G, Zappella M, Broccoli V, Renieri A, Kilstrup-Nielsen C, Landsberger N (2005)

CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome.

Hum Mol Genet 14(14):1935-46.


Danek A, Jung HH, Melone MA, Rampoldi L, Broccoli V, Walker RH (2005)

Neuroacanthocytosis: new developments in a neglected group of dementing disorders.

J Neurol Sci 229-230:171-86.


Colombo E, Galli R, Cossu G, Gécz J, Broccoli V (2004)

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.

Dev Dyn 231(3):631-9.


Ferreirinha F, Quattrini A, Pirozzi M, Valsecchi V, Dina G, Broccoli V, Auricchio A, Piemonte F, Tozzi G, Gaeta L, Casari G, Ballabio A, Rugarli EI (2004)

Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport.

J Clin Invest 113(2):231-42.


Di Cunto F, Ferrara L, Curtetti R, Imarisio S, Guazzone S, Broccoli V, Bulfone A, Altruda F, Vercelli A, Silengo L (2003)

Role of citron kinase in dendritic morphogenesis of cortical neurons.

Brain Res Bull 60(4):319-27.


Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W.

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

J Neuroscience 23(10):4199-207.


Maretto S, Cordenonsi M, Dupont S, Braghetta P, Broccoli V, Hassan AB, Volpin D, Bressan GM, Piccolo S (2003)

Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors.

Proc Natl Acad Sci U S A 100(6):3299-304.


Corradi A, Croci L, Broccoli V, Zecchini S, Previtali S, Wurst W, Amadio S, Maggi R, Quattrini A, Consalez GG. (2003)

Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.

Development 130(2):401-10.


Broccoli V, Colombo E, Cossu G (2002)

Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures.

Mech Dev 114(1-2):219-23.


Minasi MG, Riminucci M, De Angelis L, Borello U, Berarducci B, Innocenzi A, Caprioli A, Sirabella D, Baiocchi M, De Maria R, Boratto R, Jaffredo T, Broccoli V, Bianco P, Cossu G (2002)

The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues.

Development 129(11):2773-83.


Galli R, Fiocco R, De Filippis L, Muzio L, Gritti A, Mercurio S, Broccoli V, Pellegrini M, Mallamaci A, Vescovi AL (2002)

Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system.

Development 129(7):1633-44.


Barbieri AM, Broccoli V, Bovolenta P, Alfano G, Marchitiello A, Mocchetti C, Crippa L, Bulfone A, Marigo V, Ballabio A, Banfi S (2002)

Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma.

Development 129(3):805-13.


den Hollander AI, Ghiani M, de Kok YJ, Wijnholds J, Ballabio A, Cremers FP, Broccoli V (2002)

Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain.

Mech Dev 110(1-2):203-7.


Andreazzoli M, Broccoli V, Dawid IB (2001)

Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA.

Mech Dev 104(1-2):117-20.


Acampora D, Gulisano M, Broccoli V, Simeone A (2001)

Otx genes in brain morphogenesis.

Prog Neurobiol 64(1):69-95.


Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F (2000)

Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

Neuron 28(1):115-27.


Buchner G, Broccoli V, Bulfone A, Orfanelli U, Gattuso C, Ballabio A, Franco B (2000)

MAEG, an EGF-repeat containing gene, is a new marker associated with dermatome specification and morphogenesis of its derivatives.

Mech Dev 98(1-2):179-82.


Bulfone A, Menguzzato E, Broccoli V, Marchitiello A, Gattuso C, Mariani M, Consalez GG, Martinez S, Ballabio A, Banfi S (2000)

Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS.

Hum Mol Genet 9(9):1443-52.


Broccoli V (1999)

Evolutionary developmental biology of the cerebral cortex.

Bioessays 21(11):974-7.


Broccoli V, Boncinelli E, Wurst W (1999)

The caudal limit of Otx2 expression positions the isthmic organizer.

Nature 401(6749):164-8.